Murphy is roughly centrally located between Chattanooga, Tennessee and Asheville, North Carolina on US Hwy 64, which turns south and east at Murphy and goes through Hayesville on its way to Franklin and places east. Proceeding east along Hwy 19/74 takes your through Andrews, the Nantahala Gorge, and on to Asheville.
It sounds complicated, but it isn't. The four-lane highway running east and west through Murphy takes you from Chattanooga to Asheville or vice-versa with no turns. It's just the numbers on the road that change.
Murphy is also located about 100 miles or so from Knoxville, Tennessee; Greenville, South Carolina; and Atlanta, Georgia. Travel to these towns is a bit more complicated because of the lack of highways.
The roads in and out of Murphy are generally well-maintained and are of good quality. In the winter, it may take a few hours or a day to clear the roads for travel after a snow-storm, but it rarely takes much longer.
There is a small airport near Andrews, North Carolina about 15 miles that is being expanded to handle commuter jets and is perfectly suited to smaller private planes.
